GCCCD Drugs Successful in Preventing Depression Recurrence Relative to Placebo Lab Report

Description

Learn by DoingIn this activity, you will investigate the first question related to the study described below.Some features of this activity may not work well on a cell phone or tablet. We highly recommend that you complete this activity on a computer.Here are the directions and grading rubric for the Learn by Doing discussion board exercises.A list of StatCrunch directions is provided at the bottom of this page.CONTEXTClinical depression is a recurrent illness requiring treatment and often hospitalization. Nearly 50% of people who have an episode of major depression will have a recurrence within 2-3 years. Being able to prevent the recurrence of depression in people who are at risk for the disease would go a long way to alleviate the pain and suffering of patients.

During the 1980’s the federal government, through the National Institutes of Health (NIH), sponsored a large clinical trial to evaluate two drugs for depression. There were 3 treatment groups. Patients received either Imipramine (Imip), Lithium (Li), or a Placebo (Pl). Researchers randomly assigned patients to one of the 3 treatment groups and followed them for 2-4 years to track any recurrences of depression.
(Prien et al., Archives of General Psychiatry, 1984).VARIABLESHospt: Which hospital the patient was from: Labeled 1, 2, 3, 5 or 6Treat: 0=Lithium; 1=Imipramine; 2=PlaceboOutcome: 0=Success 1=Failure (recurrence of depression)Time: Number of weeks until a recurrence (if outcome=1) or until study ended (if outcome=0)AcuteT: How long the patient was depressed before the start of the current study, measured in daysAge: Age in yearsGender: 1=Female 2=MaleDATAIf you have not done so already, download the depression datafile (as always, if a login box opens, just close it and then download the file). Then upload the file in StatCrunch.PROMPTWe will analyze the data to answer the 1st research question: Which of the drugs (if either) was more successful in preventing the recurrence of depression relative to the placebo?In the previous lab-preparation activity, we determined that we will analyze the data using a two-way table and conditional percentages.Use StatCrunch to produce a two-way contingency table. (directions)
Copy the table in your StatCrunch output window and paste it in your initial discussion post. (directions)
After you paste the content of the your StatCrunch output window into your discussion post, keep the table titled Contingency table results: and delete the Chi-Square results: table.Analyze the data in your two-way table by finding appropriate conditional percentages. Write each conditional percentage as a ratio (e.g. 25 out of 40) and as a percentage (e.g. 25/40 = 62.5%). Then write a sentence that explains the meaning of the percentage in the context of the research question.Draw a conclusion. Based on this study, which drug was the most effective in preventing the recurrence of depression? Support your conclusion using conditional percentages.LIST OF STATCRUNCH DIRECTIONSEach link will open in a new window. To return to this discussion, either close the new tab or select the tab for this discussion.Create Your Stats-Class Folder in Canvas (You only need to do this once.)Purchase StatCrunch (You only need to do this once.)Open StatCrunchDownload Excel Data FileUpload Excel Data File to StatCrunchDownload StatCrunch Output Window (no screenshots; please use these directions)Upload Files into Your Stat-Class Folder in CanvasEmbed Pictures in a Discussion Post (no attachments; please use these directions)Create a Two-way Contingency Table with DataCopy & Paste a StatCrunch TableHere is a PDF document with all StatCrunch directions (Links to an external site.).

Tags:
placebo

lithium

Imipramine

Two way contingency table

recurrence of depression

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